Gliosarcomas: Analysis of Braga Hospital Cases and Review of the Literature

Background: Gliosarcomas are very rare tumors of central nervous system, as such, the data of the literature are scarce, which makes its characterization and therapeutic approach more difficult.

Methods: A survey about gliosarcomas in Hospital de Braga was carried out between January 1995 and October 2013. A bibliographic review was also carried out.

Results: We get a total of 18 cases and the main aim of this study was to evaluate survival according to different variables (age, gender, time symptoms to diagnose, karnofsky, MRI necrosis, MRI mass effect, MRI edema, proximity to the dura-mater, lobar location, hemispheric location, tumor size, gliosarcoma type, macroscopy, type of resection, adjuvant treatment and metastization). The factors associated with a better survival were: age inferior to 50 years old, female gender, karnofsky >80, time symptoms to diagnose <1 month, necrosis <50% tumor volume, midline shift <0.5 cm, edema<tumor volume, tumor not adjacent to the dura-mater, size <5 cm, occipital lobe, left hemisphere, primary type, macroscopy similar to glioblastoma, radical resection, adjuvant RT, non metastization. There were two factors with influence on survival and statistically significant p value: midline shift less than 0.5 cm and location in the left hemisphere.

Conclusion: This sample presents some factors with effect on the survival and that can be taken into account in the approach of these tumors.


Rui Manue Almeida Ramos, Maria João Machado, Hugo Pereira, Renata arques, Cristiano Antunes, Ricardo Moreira, Afonso Almeida Pinto, Marta Almeida, úlia Amorim, Carlos Alegria, Rui Almeida and Vânia Magalhães

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